Overview
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding tripeptide first isolated from human plasma in the 1970s. It is one of the most extensively published compounds in regenerative biology and wound healing research, with peer-reviewed studies spanning collagen synthesis, gene expression regulation, anti-inflammatory signaling, and tissue repair across multiple organ systems. Its high copper-binding affinity and broad gene expression effects have made it a reference compound in copper compound biology for over five decades. Alpha Tides supplies GHK-Cu as a 50mg lyophilized powder for laboratory research use.
Research Applications
- Wound healing and tissue repair: In vitro and preclinical models of skin repair, wound closure, and dermal remodeling
- Collagen and glycosaminoglycan synthesis: Fibroblast activation and extracellular matrix production studies
- Anti-inflammatory signaling: Studies on NF-kB pathway modulation and pro-inflammatory cytokine suppression
- Gene expression regulation: GHK-Cu has been shown to modulate over 4,000 human genes in expression studies
- Antioxidant and DNA repair pathways: Superoxide dismutase activation and oxidative stress response studies
- Neuroprotection research: Preliminary studies on nerve regeneration and neurotrophic factor interactions
- Hair follicle biology: Follicle stimulation and scalp tissue research models
- Pulmonary biology: COPD and lung tissue repair research using GHK-Cu as a model compound
Research Notes
GHK-Cu facilitates copper transport into cells, where it activates enzymes involved in collagen and elastin synthesis. Expression studies have identified GHK-Cu as influencing over 4,000 human genes, including those governing anti-inflammatory cascades, antioxidant defense systems, and DNA repair mechanisms — making it one of the most broad-spectrum regulatory compounds characterized in the literature.
GHK-Cu was first characterized by Loren Pickart in 1973 and has since accumulated one of the largest peer-reviewed research bases of any copper compound, with published studies spanning dermatology, oncology, neurology, wound healing, and pulmonary biology. The 50mg vial format is particularly suited to researchers running longer-duration protocols, multi-condition studies, or work requiring repeated consistent dosing across assay runs.
Storage Notes
- Before reconstitution: Store lyophilized vials at −20°C, protected from light and moisture. Allow to reach room temperature before opening.
- After reconstitution: Refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
- Long-term storage: Freeze at −20°C for storage beyond 30 days.
Related Research
- How to Store Research Compounds Properly — Storage protocols for lyophilized compounds
- How to Reconstitute Lyophilized Compounds — Step-by-step reconstitution guide
- Research Hub — Full library of compound guides and research references
GHK-Cu is intended strictly for laboratory research by qualified professionals. It is not FDA approved and is not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms the product will be used solely for in vitro research in compliance with all applicable laws.
