Overview
HCG 1000 is a research-grade Human Chorionic Gonadotropin compound supplied as 1000 IU of lyophilized powder per vial. HCG is a glycoprotein hormone with direct binding affinity for the luteinizing hormone/choriogonadotropin receptor (LHCGR), making it one of the most studied compounds in reproductive endocrinology, gonadal function research, and HPG axis studies. Its longer biological half-life compared to endogenous LH — a consequence of its sialic acid-rich beta subunit — produces more sustained receptor stimulation, making it a reliable reference compound for studying prolonged gonadotropin activity.
Alpha Tides supplies HCG 1000 as lyophilized powder for laboratory research use.
Research Applications
- Gonadal function research: Leydig cell steroidogenesis stimulation and testosterone production pathway studies
- HPG axis dynamics: Hypothalamic-pituitary-gonadal axis interaction and feedback loop studies
- Male reproductive endocrinology: Spermatogenesis support mechanisms and testicular function models
- Female reproductive endocrinology: Follicular maturation, ovulation triggering mechanisms, and corpus luteum function studies
- Endocrine recovery models: Studies on gonadal function recovery following hormonal suppression
- Receptor binding studies: LHCGR characterization and downstream cAMP signaling kinetics
- Steroidogenesis research: StAR protein expression and cholesterol transport pathway studies
Research Notes
HCG mimics endogenous LH by binding to LHCGR on Leydig cells in the testes and theca cells in the ovaries, triggering downstream cAMP signaling that stimulates steroidogenesis — the production of testosterone and other sex hormones. The sialic acid-rich beta subunit of HCG confers a half-life of approximately 24–36 hours, compared to less than one hour for LH — making it especially useful for sustained gonadotropin stimulation protocols in preclinical research.
HCG has been used in reproductive endocrinology research since the 1960s and remains one of the most extensively referenced gonadotropin compounds in the peer-reviewed literature. Its well-characterized receptor binding profile and predictable downstream signaling make it a reliable reference and experimental compound for HPG axis studies, Leydig cell function research, and steroidogenesis pathway investigation.
Storage Notes
- Before reconstitution: Store lyophilized vials at −20°C, away from light and moisture. Allow to reach room temperature before opening.
- After reconstitution: Refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
- Long-term storage: Keep frozen at −20°C for storage beyond 30 days.
Related Research
- How to Store Research Compounds Properly — Storage protocols for lyophilized compounds
- How to Reconstitute Lyophilized Compounds — Step-by-step reconstitution guide
- Research Hub — Full library of compound guides and research references
HCG 1000 is intended strictly for laboratory research by qualified professionals. It is not FDA approved and is not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms the product will be used solely for in vitro research in compliance with all applicable laws.
