Overview
MT-II (Melanotan II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (Ξ±-MSH), originally developed at the University of Arizona. As a non-selective melanocortin receptor agonist, MT-II binds MC1R, MC3R, MC4R, and MC5R β making it a versatile research tool for studying the breadth of melanocortin receptor biology. Its cyclic structure enhances blood-brain barrier permeability and extends half-life compared to linear melanocortin analogs. Alpha Tides supplies MT-II as a 10mg lyophilized powder for laboratory research use.
Research Applications
- Melanocortin receptor pharmacology: Non-selective agonist for comparative MC1R/MC3R/MC4R/MC5R binding and activation studies
- Pigmentation biology: MC1R-mediated adenylate cyclase signaling and melanin synthesis pathway studies
- Neuroendocrine research: MC4R activation in hypothalamic energy balance, appetite regulation, and pituitary signaling models
- Immune signaling: Melanocortin pathway involvement in inflammatory cytokine modulation
- Neuroinflammation models: Central nervous system melanocortin receptor activity studies
- Derivative compound comparison: Reference compound for studies comparing MT-II to receptor-selective derivatives such as PT-141 (Bremelanotide)
Research Notes
MT-II acts as a potent non-selective agonist across the melanocortin receptor family. Activation of MC1R initiates adenylate cyclase signaling, increasing intracellular cyclic AMP β a cascade that activates downstream enzymes controlling melanin synthesis. MC3R and MC4R activation has been studied in neuroendocrine contexts, particularly in relation to energy balance, appetite, and hypothalamic-pituitary axis communication.
MT-II non-selective receptor profile makes it a valuable research tool for characterizing melanocortin system-wide responses compared to receptor-selective derivatives. It has been used as a reference compound in numerous receptor pharmacology and functional selectivity studies. Its research legacy includes serving as the structural precursor from which PT-141 (Bremelanotide) was derived β a modification designed to isolate MC4R-mediated effects while minimizing peripheral MC1R pigmentation activity.
The compound has been the subject of peer-reviewed research spanning pigmentation biology, neuroendocrine function, immune signaling, and metabolic regulation for over three decades.
Storage Notes
- Before reconstitution: Store lyophilized vials at β20Β°C, protected from light and moisture. Allow to reach room temperature before opening.
- After reconstitution: Refrigerate at 2β8Β°C and use within 28 days. Avoid repeated freeze-thaw cycles.
- Recommended solvent: Bacteriostatic water.
Related Research
- PT-141 vs MT-II research comparison β How the two compounds differ in receptor selectivity and CNS activity
- How to Store Research Compounds Properly β Storage protocols for lyophilized compounds
- How to Reconstitute Lyophilized Compounds β Step-by-step reconstitution guide
- Research Hub β Full library of compound guides and research references
MT-II is intended strictly for laboratory research by qualified professionals. It is not FDA approved and is not for human or animal use. By purchasing, the buyer confirms the product will be used solely for in vitro research in compliance with all applicable laws and regulations.
