Overview
NAD+ 500mg (Nicotinamide Adenine Dinucleotide) is a research-grade lyophilized coenzyme available exclusively for laboratory and scientific research purposes. Alpha Tides PNW supplies NAD+ as a 500mg lyophilized powder for laboratory research use. A Certificate of Analysis is available for this product.
What Is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell and one of the most actively researched molecules in modern longevity and metabolic biology. NAD+ functions as a critical electron carrier in redox reactions and serves as a substrate for key enzymes including sirtuins, PARPs, and CD38 — all of which are linked to DNA repair, gene expression regulation, and cellular stress response.
Research indicates that NAD+ levels decline substantially with age, driven by increased CD38 activity, chronic inflammation, and reduced biosynthesis. This age-related decline has made NAD+ a primary focus of studies examining metabolic health, mitochondrial function, cognitive performance, and cellular energy production in preclinical models.
Research Areas
NAD+ has been the subject of extensive preclinical research across multiple biological systems:
Cellular Energy Metabolism — NAD+ plays a central role in the mitochondrial electron transport chain, directly supporting ATP production. Preclinical studies have examined how restoring NAD+ levels influences mitochondrial efficiency and overall cellular energy output in aged tissue models.
Sirtuin Activation — Sirtuins (SIRT1–SIRT7) are NAD+-dependent enzymes that regulate gene expression, inflammation, and metabolic homeostasis. Research has investigated how NAD+ availability influences sirtuin activity and downstream effects on cellular aging pathways.
DNA Repair via PARP Activation — PARP enzymes consume NAD+ during DNA damage repair. Studies have examined the relationship between NAD+ availability and PARP-mediated repair efficiency, particularly in models of oxidative stress and genomic instability.
Mitochondrial Function — Research has explored NAD+’s role in maintaining mitochondrial membrane potential, biogenesis, and function. Preclinical models have shown that NAD+ repletion may support mitochondrial health in aging and metabolic dysfunction models.
Redox Signaling — As a key electron carrier cycling between NAD+ and NADH, this coenzyme is central to cellular redox balance. Studies have examined its role in regulating oxidative stress responses across multiple tissue types.
Route of Administration Research — Comparative studies examining different NAD+ delivery methods — including direct NAD+ versus precursor compounds such as NMN and NR — are an active area of pharmacokinetic research, investigating differences in absorption and metabolic conversion pathways.
Cognitive and Neuroprotective Research — Animal studies have examined NAD+’s potential neuroprotective properties, with researchers investigating its role in supporting neuronal energy metabolism and resilience against age-related cognitive decline.
Storage & Handling
- Before reconstitution: Store lyophilized vials at −20°C, protected from heat and light. Allow to reach room temperature before opening.
- After reconstitution: Refrigerate at 2–8°C and minimize exposure to light. Avoid repeated freeze-thaw cycles.
- Recommended solvent: Bacteriostatic water.
Related Research
- NAD+ and Cellular Energy in Research Models — Mechanisms and study context
- How to Reconstitute Lyophilized Compounds — Step-by-step reconstitution protocol
- How to Store Research Compounds Properly — Storage and stability guidance
- Certificates of Analysis — Batch-specific third-party test results
This product is intended strictly for research use only (RUO). Not for human consumption, veterinary use, or household use. For use by qualified researchers in controlled laboratory settings only. This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease or condition.
