Overview
PT-141 is a research peptide studied for pathways involved in sexual arousal and sexual-response signaling. Researchers investigate how melanocortin signaling in the brain influences these biological responses. Alpha Tides supplies PT-141 as a 10mg lyophilized powder for laboratory research use.
Technical Research Details
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from Melanotan II. It is a non-selective melanocortin receptor agonist with selective affinity for MC3R and MC4R subtypes located in the central nervous system. Unlike peripherally-acting compounds, PT-141 operates primarily via CNS-mediated pathways, making it a distinct research tool in neuropharmacology and neuroendocrine signaling studies. Alpha Tides supplies PT-141 as a 10mg lyophilized powder for laboratory research use.
Research Applications
- Melanocortin receptor pharmacology: MC3R/MC4R binding affinity studies and downstream cAMP signaling characterization
- CNS signaling research: Hypothalamic and limbic system melanocortin pathway studies
- Neuroendocrine research: Hypothalamic-pituitary axis interactions and hormonal signaling downstream of MC4R activation
- Receptor selectivity studies: Comparative pharmacological research between PT-141 and MT-II to examine structural modification effects on receptor selectivity
- Behavioral neuroscience: Animal model research examining MC3R/MC4R involvement in reward and motivated behaviors
- Autonomic nervous system studies: Downstream autonomic regulation mediated via hypothalamic melanocortin receptor activation
Research Notes
PT-141 was developed as a structural modification of Melanotan II (MT-II) with the specific goal of isolating CNS melanocortin receptor activity while reducing peripheral MC1R pigmentation effects. Its cyclic compound structure enhances central nervous system penetration relative to linear melanocortin analogs.
Research into MC3R and MC4R has expanded significantly in the context of neuroendocrine regulation. MC4R is expressed throughout the hypothalamus and limbic system and has been implicated in energy homeostasis, stress response, and autonomic output regulation in numerous preclinical studies. PT-141’s well-characterized receptor pharmacology provides a strong reference point for researchers designing preclinical studies.
Storage Notes
- Before reconstitution: Store lyophilized at −20°C, protected from light and moisture. Allow to reach room temperature before opening.
- After reconstitution: Refrigerate at 2–8°C and use within 14 days. Avoid repeated freeze-thaw cycles.
- Recommended solvent: Bacteriostatic water only. Handle under sterile laboratory conditions.
Related Research
- MT-II and PT-141 comparison guide — How the two compounds differ in receptor selectivity and CNS activity
- How to Store Research Compounds Properly — Storage protocols for lyophilized research compounds
- How to Reconstitute Lyophilized Compounds — Step-by-step reconstitution guide
- Research Hub — Full library of compound guides and research references
PT-141 is intended strictly for laboratory research by qualified professionals. It is not FDA approved and is not for human or animal use. By purchasing, the buyer confirms the product will be used solely for in vitro research in compliance with all applicable laws and regulations.
