Tesamorelin is a synthetic 44-amino acid analog of growth hormone-releasing hormone (GHRH), developed by Theratechnologies. It received FDA approval in 2010 under the brand name Egrifta, making it the only GHRH analog to achieve regulatory approval for clinical use — specifically for HIV-associated lipodystrophy. It remains one of the most extensively studied synthetic GHRH peptides in the research literature.
How It Works
What separates Tesamorelin from native GHRH is one key structural modification. Native GHRH is rapidly cleaved by an enzyme called dipeptidyl peptidase IV (DPP-IV), which renders it biologically inactive within minutes. By capping the N-terminus with trans-3-hexenoic acid, Tesamorelin blocks DPP-IV from making that cut — resulting in a longer-acting, structurally intact GHRH analog that retains full receptor binding capacity.
Once active, Tesamorelin activates GHRH receptors in the pituitary, leading to synthesis and release of growth hormone, which in turn stimulates production of insulin-like growth factor-1 (IGF-1) in the liver. Importantly, this mechanism works upstream — stimulating the body’s own GH secretion rather than introducing exogenous hormone, which preserves the natural pulsatile rhythm of GH release.
Where the Research Stands
Tesamorelin has Phase 2 and Phase 3 clinical trial data behind it — unusually robust for a research peptide. Phase 3 data showed a 15.2% reduction in visceral fat and a 37% relative reduction in liver fat. Beyond its approved indication, researchers have studied it in contexts including hepatic lipid metabolism, muscle composition, neuroendocrine signaling, and age-related changes in GH axis regulation.
Product Details
- Form: Lyophilized powder
- Size: 10mg per vial
- Purity: ≥99% | COA available on request
- Storage: Keep dry and away from light before reconstitution. Refrigerate after reconstitution.
Research Use Only
Tesamorelin is intended strictly for laboratory research by qualified professionals. Outside of its FDA-approved pharmaceutical form for lipodystrophy, it is not for human or animal use. By purchasing, the buyer confirms the product will be used solely for in vitro research in compliance with all applicable laws and regulations.
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